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KMID : 0369819780080010127
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Jorunal of Korean Pharmaceutical Sciences
1978 Volume.8 No. 1 p.127 ~ p.136
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Pharmaceutical Studies on Anti - inflammatory Enzyme Preparations
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이강춘/Lee KC
양중익/민신홍/이상희/김용배/Yang JI/Min SH/Rhee SH/Kim YB
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Abstract
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Spherical granules of anti-inflammatory enzyme were prepared by mixer granulation and the recovery rate of enzyme activity by processing was compared with tablet ones. In the enteric granule coating .processing, the effect of the amount of coating solution and the conentration of fatty alcohol on disintegration and stabilities on the accelerated conditions were also studied. Being prepared in non-pressure and non-aqueous condition, spherical granules of enzyme made better recovery of enzme activity than tablet ones by 10 times. Combined processing of both mixer granulation and enteric granule film coating provided the noble enteric coated granules, in the sense of disintegration and stabilities, was obtained from using 0.125% fatty alcohol in coating solution.
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